【摘要】 目的分析中国2015-2017年无细胞百白破联合疫苗(Diphtheria, tetanus and acellular pertussis combined vaccine,DTaP)疑似预防接种异常反应(AdverseEventFollowingImmunization,AEFI)发生特征。方法通过中国免疫规划信息管理系统收集2015-2017年报告的DTaP AEFI个案和接种数据,进行描述流行病学分析。结果中国2015-2017年共报告DTaP AEFI 170 743例,报告发生率为79.64/10万剂;其中一般反应163 764例(95.91%,76.38/10万剂),异常反应5 841例(3.42%,2.72/10万剂)。在异常反应中,严重异常反应268例(0.13/10万剂);过敏性皮疹4 798例(2.24/10万剂)、血管性水肿348例(0.16/10万剂)、无菌性脓肿146例(0.07/10万剂)、血小板减少性紫癜89例(0.04/10万剂)、热性惊厥88例(0.04/10万剂)。结论中国2015-2017年DTaP AEFI报告发生率在预期范围内,严重异常反应极其罕见。更多还原

【Abstract】 Objective To determine characteristics of adverse events following immunization(AEFIs) with diphtheria, tetanus and acellular pertussis combined vaccine(DTaP) during 2015-2017 in China. Methods We obtained DTaP AEFI and vaccination data that were reported to the China Immunization Program Information Management System during 2015-2017 f or a descriptive, epidemiological analysis. Results In total, 170 743 DTaP AEFIs were reported during 2015-2017 in China f or an incidence of 79.64 cases per 100 000 doses, with 163 764 cases(95.91% of cases, 76.38 per 100 000) being common vaccine reactions and 5 841 cases(3.42% of cases, 2.72 per 100 000) being rare vaccine reactions. Of the rare reactions, 268(0.13 per 100 000) were severe, rare reactions; 4 798(2.24 per 100 000), 348(0.16 per 100 000), 146(0.07 per 100 000), 89(0.04 per 100 000), and 88 cases(0.04 per 100 000) were allergic rash, vascular edema, aseptic abscess, thrombocytopenic purpura, and febrile convulsion, respectively. Conclusion The incidence of DTaP AEFI was not higher than the expected; severe rare reactions were extremely rare.更多还原